Journal article
Neural correlates of obsessive-compulsive related dysfunctional beliefs
P Alonso, A Orbegozo, J Pujol, C López-Solà, MA Fullana, C Segalàs, E Real, M Subirà, I Martínez-Zalacaín, JM Menchón, BJ Harrison, N Cardoner, C Soriano-Mas
Progress in Neuro Psychopharmacology and Biological Psychiatry | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2013
Abstract
There have been few attempts to integrate neurobiological and cognitive models of obsessive-compulsive disorder (OCD), although this might constitute a key approach to clarify the complex etiology of the disorder. Our study aimed to explore the neural correlates underlying dysfunctional beliefs hypothesized by cognitive models to be involved in the development and maintenance of OCD. We obtained a high-resolution magnetic resonance image from fifty OCD patients and 30 healthy controls, and correlated them, voxel-wise, with the severity of OC-related dysfunctional beliefs assessed by the Obsessive Beliefs Questionnaire-44. In healthy controls, significant negative correlations were observed b..
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Grants
Awarded by Agència de Gestió d'Ajuts Universitaris i de Recerca
Funding Acknowledgements
This work was supported in part by the Carlos III Health Institute (PI09/01331 and CP10/00604, PI10/01753, PI10/01003, CIBER-CB06/03/0034) and by Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR; 2009SGR1554). Dr. Soriano-Mas is funded by a Miguel Servet contract from the Carlos III Health Institute (CP10/00604). Dr. Harrison is supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award (I.D. 628509). The sponsors had no role in the study design, collection, analysis and interpretation of the data, in writing the report or in the decision to submit it for publication.